Extreme parasitemia in P falciparum malaria
نویسندگان
چکیده
منابع مشابه
Relationship of hepcidin with parasitemia and anemia among patients with uncomplicated Plasmodium falciparum malaria in Ghana.
The pathogenesis of malarial anemia is incompletely understood. Hepcidin, a recently discovered peptide hormone, is a major regulator of iron metabolism and is thought to play a central role in the anemia of chronic inflammation. The specific aim of the study was to characterize the association between urinary hepcidin, hemoglobin, and parasitemia in 199 patients presenting for evaluation of Pl...
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BACKGROUND Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated falciparum malaria treated with quinine. METHODS Fifty-six adult patients with severe malaria and...
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To define the frequency of the early rising of parasitemia in falciparum malaria patients treated with artemisinin derivatives, a retrospective chart review of 497 patients admitted to the Hospital for Tropical Diseases, Bangkok in 1996 was carried out. Early rising parasitemia, defined as an increase in the parasite count over the baseline pretreatment level during the first 24 hours of treatm...
متن کاملHemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack.
Genetic predisposition to malaria has been shown by epidemiological, case-control and linkage studies. In particular, case-control studies have recently shown association between hemoglobin C and resistance to severe malaria in Mali and to clinical malaria in Burkina Faso. In a longitudinal study of families living in an endemic area, we investigated whether hemoglobin C is associated with redu...
متن کاملTherapy of Plasmodium falciparum parasitemia with desferrioxamine.
Recently Gordeuk et all have observed a drastic increase of the rate of parasite clearance in patients with asymptomatic Plasmodium falcipanun infection. They suggested that this may be partially caused by limitation of iron by chelation, although they argued that this may not be the only mechanism limiting growth of P falcipanun. Previous studies have shown elevated levels of neopterin in urin...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-07-861880